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pentobarbital will reduce the extent or influence of nilotinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital will decrease the extent or result of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with potent CYP3A4 inducers is just not recomme